He has been recovering from a calf injury but is in the squad that travelled to Manchester for the heavyweight Group A encounter.
City will advance to the knockout stage if they avoid defeat.
Pep Guardiola’s side will also make the last 16 if Club Bruges fail to beat RB Leipzig in the other game in Group A.
‘Past results will have no bearing’
PSG boss Mauricio Pochettino arrives in Manchester amid widespread speculation linking him with the vacant manager’s job at Manchester United.
Former Tottenham boss Pochettino inspired PSG to a 2-0 win over City at Parc des Princes in September, although the group has since turned round with City now in top spot and needing only a point from their second meeting to advance.
Guardiola insists his past meetings with the Argentine will have no bearing on this latest clash.
“It’s completely different – different countries, players, shapes,” he said.
“Even with the same manager and same team from one year it can be different – new players, many things can happen.”
City will check on record signing Jack Grealish before the game.
The England midfielder missed Sunday’s Premier League victory over Everton with a knock sustained on international duty but is hoping to return in time to face PSG.
Kevin de Bruyne (coronavirus) is unavailable and winger Ferran Torres (foot) may be out until the new year.
Match facts – another Messi goal against City?
PSG’s Lionel Messi has scored seven goals in seven Champions League appearances against Manchester City.
Manchester City’s Joao Cancelo has been directly involved in five goals in his past four Champions League appearances for Manchester City (two goals and three assists), including a hat-trick of assists in his last game against Club Bruges.
Paris St-Germain have only won 20% of their meetings with Manchester City in the Champions League. Among teams they have faced at least five times in the competition, only against Real Madrid (17%) do they have a lower win percentage.
PSG are winless in their past three away games in the Champions League (D2 L1), and could go without an away victory in the group stage of the competition in a single season for the first time since 2004-05.